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Article

AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.

Investigative ophthalmology & visual science - 3 Jul 2023

Grigsby Daniel, Klingeborn Mikael, Kelly Una, Chew Lindsey A, Asokan Aravind, Devlin Garth, Smith Sharon, Keyes Lisa, Timmers Adrian, Scaria Abraham, Bowes Rickman Catherine

Abstract excerpt

Purpose: Complement dysregulation in the eye has been implicated in the pathogenesis of age-related macular degeneration (AMD), and genetic variants of complement factor H (CFH) are strongly associated with AMD risk. We therefore aimed to untangle the role of CFH and its splice variant, factor H-like 1 (FHL-1), in ocular complement regulation derived from local versus circulating sources. We assessed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37471073
DOI: 10.1167/iovs.64.10.25
PMCID: PMC10365136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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