Article
Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.
Annals of medicine - 1 Jan 2006
Hageman Gregory S, Hancox Lisa S, Taiber Andrew J, Gehrs Karen M, Anderson Don H, Johnson Lincoln V, Radeke Monte J, Kavanagh David, Richards Anna, Atkinson John, Meri Seppo, Bergeron Julie, Zernant Jana, Merriam Joanna, Gold Bert, Allikmets Rando, Dean Michael
Abstract excerpt
BACKGROUND: Variants in the complement factor H gene (CFH) are associated with age-related macular degeneration (AMD). CFH and five CFH-related genes (CFHR1-5) lie within the regulators of complement activation (RCA) locus on chromosome 1q32. Aims and Methods. In this study, the structural and evolutionary relationships between these genes and AMD was refined using a combined genetic, molecular and...
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