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Article

Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.

Investigative ophthalmology & visual science - 1 Nov 2010

Ufret-Vincenty Rafael L, Aredo Bogale, Liu Xinran, McMahon Anne, Chen Peter W, Sun Hui, Niederkorn Jerry Y, Kedzierski Wojciech

Abstract excerpt

PURPOSE: Complement factor H (Cfh) is a key regulator of the alternative complement pathway. A Cfh variant (Y402H) increases the risk for AMD. The purpose of this study was to develop a pathophysiologically relevant animal model of AMD based on this genetic risk factor. METHODS: The authors generated chimeric Cfh transgenic mouse lines using two constructs consisting of the human CFH sequence for SCR6-8 (with...

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Source

Identifiers

PMID: 20538999
DOI: 10.1167/iovs.09-4457

Genes

CFH
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.PMID 20538999Read ↗

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Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in miceSemantic proximity Read ↗

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Complement factor H in AMD: Bridging genetic associations and pathobiology.Semantic proximity Read ↗

The Noncanonical Role of Complement Factor H in Retinal Pigment Epithelium (RPE) Cells and Implications for Age-Related Macular Degeneration (AMD).Semantic proximity Read ↗

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