Article
Single tube genotyping of CYP2A6 gene deletion based on copy number determination by quantitative real-time PCR.
Experimental and molecular pathology - 1 Dec 2014
Liu Jin-hui, Xun Xiao-jie, Pang Cong, Ma Jun, Zou Hui, Chen Chao, Dai Peng-gao
Abstract excerpt
The CYP2A6*4 allele, characterized as the whole deletion of this gene, is closely associated with nicotine dependence, cancer susceptibility, and drug responsiveness. It has long been a significant challenge for pharmacogenetics scientists to develop a reliable method to detect this molecular variant due to its high homology with its homologous genes CYP2A6 and CYP2A3 in the clinical setting. Here, we introduce a...
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