Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR.

Human mutation - 1 Dec 2003

Schaeffeler Elke, Schwab Matthias, Eichelbaum Michel, Zanger Ulrich M

Abstract excerpt

The genetic polymorphism of the cytochrome P450 monooxygenase, CYP2D6, comprises at least 43 alleles giving rise to distinct drug metabolism phenotypes termed ultrarapid, extensive, intermediate, and poor metabolizers. As a consequence, drug side effects or lack of drug effect may occur if standard doses are applied. Genetic prediction of drug oxidation phenotype as a basis for dose selection requires analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Frequency

Share to Polymerase Chain Reaction

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 14635107
DOI: 10.1002/humu.10280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR.PMID 14635107Read ↗

A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication.Semantic proximity Read ↗

Unique Genotyping Protocol of CYP2D6 Allele Frequency Using Real Time Quantitative PCR from Japanese Healthy Women.Semantic proximity Read ↗

Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis.Semantic proximity Read ↗

CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection.Semantic proximity Read ↗

Rapid and reliable genotyping procedure for detection of alleles with mutations, deletion, or/and duplication of the CYP2D6 gene.Semantic proximity Read ↗

CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.Semantic proximity Read ↗

Single tube genotyping of CYP2A6 gene deletion based on copy number determination by quantitative real-time PCR.Semantic proximity Read ↗

Pharmacogenetic screening of the gene deletion and duplications of CYP2D6.Semantic proximity Read ↗

A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis.Semantic proximity Read ↗

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.Semantic proximity Read ↗

Rapid detection of common cytochrome P450 2D6 alleles in Caucasians.Semantic proximity Read ↗

Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.