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Article

Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis.

Analytical biochemistry - 1 Jun 2009

Leandro-García Luis J, Leskelä Susanna, Montero-Conde Cristina, Landa Iñigo, López-Jimenez Elena, Letón Rocío, Seeringer Angela, Kirchheiner Julia, Cascón Alberto, Robledo Mercedes, Rodríguez-Antona Cristina

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) copy number variation (CNV) influences the metabolism of 15-25% of clinical drugs. Here we describe a novel multiplex polymerase chain reaction (PCR) analysis method that accurately detects CYP2D6 CNV and CYP2D6*9 allele. It includes the amplification of 2 CYP2D6 and 7 control (AQP1, CYP3A4, MDR1, and SDHB) fluorescent PCR products that are separated on a capillary sequencer and...

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Share to Cytochrome P-450 CYP2D6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 19303860
DOI: 10.1016/j.ab.2009.03.021

Genes

AQP1
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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