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Article

Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness.

International journal of molecular sciences - 26 Nov 2014

Zhang Enhao, Zhang Jihang, Jin Jun, Qin Jun, Li Huijie, Huang Lan

Abstract excerpt

Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS). Here, we aimed to analyze single nucleotide polymorphisms (SNPs) in the untranslated regions of the EGLN1 and HIF-1AN genes and SNPs chosen from a genome-wide adaptation...

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Source

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Identifiers

PMID: 25431923
DOI: 10.3390/ijms151221777
PMCID: PMC4284677

Genes

EGLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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