Article
Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2019
Brutsaert Tom D, Kiyamu Melisa, Elias Revollendo Gianpietro, Isherwood Jenna L, Lee Frank S, Rivera-Ch Maria, Leon-Velarde Fabiola, Ghosh Sudipta, Bigham Abigail W
Abstract excerpt
Highland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO2max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nominated Egl-9 homolog 1 gene (EGLN1) as a candidate gene. The encoded protein, EGLN1/PHD2, is an O2 sensor that controls levels of the Hypoxia Inducible Factor-α (HIF-α),...
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