Article
Genome-wide association study reveals acute mountain sickness susceptibility in Chinese population.
Molecular genetics and genomics : MGG - 13 Feb 2026
Zheng Xiangyi, Song Wenyu, Li Yuanfeng, Bao Nandi, Li Wenhui, Liu Yang, Liu Juanjuan, Li Bin, Yang Xi, Han Xiaobo, Wu Jialin, Ma Liqun, Liu Ying, Jin Mei, Wang Guangyun, Yin Dongfeng, Zhou Wei, Ye Qiao, Wang Rui
Abstract excerpt
Acute mountain sickness (AMS) is a major health challenge in high-altitude environments, yet its genetic underpinnings, particularly in the Chinese population, remain poorly characterized. We conducted a genome-wide association study (GWAS) on 156 AMS patients and 313 controls in Chinese population, revealing four novel suggestive single nucleotide polymorphisms (SNPs) (P < 1 × 10- 5). Among these four SNPs, two...
Topics
- Adult
- Female
- Humans
- Male
- Acute Disease
- Alleles
- Altitude Sickness
- Case-Control Studies
- China
- Genetic Predisposition to Disease