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DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases

30 Aug 2025

Abstract excerpt

High-altitude environments, characterized by hypoxia, low temperatures, and intense ultraviolet radiation, pose significant challenges to human physiology and health. DNA methylation, as a key epigenetic regulatory mechanism, plays a central role in human adaptation to high-altitude environments and in disease pathogenesis. Current research indicates that high-altitude native populations (such as Tibetans and...

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PMID: 40886024
DOI: 10.1186/s40246-025-00794-x

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