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Article

The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction.

Human molecular genetics - 1 Aug 1998

Herrmann S M, Ricard S, Nicaud V, Mallet C, Evans A, Ruidavets J B, Arveiler D, Luc G, Cambien F

Abstract excerpt

P-selectin is an adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin expression is increased in atherosclerotic plaques, and high plasma levels of this molecule have been observed in patients with unstable angina. We investigated the P-selectin gene as a possible candidate for myocardial infarction...

Topics

Adult
Alleles
Gene Frequency
Humans
Male
Middle Aged
Myocardial Infarction
P-Selectin
Polymorphism, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9668170
DOI: 10.1093/hmg/7.8.1277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9668170-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction.PMID 9668170Read ↗

Polymorphisms of the P-selectin gene and risk of myocardial infarction in men and women in the ECTIM extension study. Etude cas-temoin de l'infarctus myocarde.Semantic proximity Read ↗

Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease.Semantic proximity Read ↗

Specific haplotypes of the P-selectin gene are associated with myocardial infarction.Semantic proximity Read ↗

The Ser290Asn and Thr715Pro Polymorphisms of the SELP Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population ‡.Semantic proximity Read ↗

Clinical and genetic correlates of soluble P-selectin in the community.Semantic proximity Read ↗

The P-selectin gene Pro715 allele and low levels of soluble P-selectin are associated with reduced P2Y12 adenosine diphosphate receptor reactivity in clopidogrel-treated patients.Semantic proximity Read ↗

P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study.Semantic proximity Read ↗

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Short alleles of P-selectin glycoprotein ligand-1 protect against premature myocardial infarction.Semantic proximity Read ↗

The P-selectin gene polymorphism Val168Met: a novel risk marker for the occurrence of primary ventricular fibrillation during acute myocardial infarction.Semantic proximity Read ↗

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