Article
The P-selectin gene Pro715 allele and low levels of soluble P-selectin are associated with reduced P2Y12 adenosine diphosphate receptor reactivity in clopidogrel-treated patients.
Atherosclerosis - 1 Jul 2011
Gremmel Thomas, Kopp Christoph W, Steiner Sabine, Seidinger Daniela, Ay Cihan, Koppensteiner Renate, Mannhalter Christine, Panzer Simon
Abstract excerpt
OBJECTIVE: To investigate the interrelation between the P-selectin gene (SELP) Pro715 allele, P2Y12 adenosine diphosphate (ADP) receptor reactivity and levels of soluble P-selectin (sP-selectin) in clopidogrel treated patients. METHODS: The Pro715 allele within SELP was tested by allele specific PCR, sP-selectin was determined by ELISA, and P2Y12 receptor reactivity was analyzed by the VASP assay in 156 patients...
Topics
- Adult
- Alleles
- Angioplasty
- Clopidogrel
- Female
- Humans
- Male
- Middle Aged
- P-Selectin
- Platelet Aggregation Inhibitors
- Polymorphism, Genetic