Clone Wars — The Emergence of Neoplastic Blood-Cell Clones with Aging

Abstract excerpt

Blood cells originate from hematopoietic stem cells (HSCs). HSCs are infrequent (<2 per 108 bone marrow cells, or about 11,000 to 22,000 per person) and rarely divide.1,2 Because mutations occur with DNA replication during cell division, HSC quiescence maximizes genomic stability and thus safety.Mutations, however, can and do occur. Most are innocuous and do not substantially alter protein quantities or...