Article

Vast population genetic diversity underlies the treatment dynamics of <i>ETV6-RUNX1</i> acute lymphoblastic leukemia

2017-03-16

Abstract excerpt

Ensemble-averaged genome profiling of diagnostic samples suggests that acute leukemias harbor few somatic genetic alterations. We used single-cell exome and error-corrected sequencing to survey the genetic diversity underlying ETV6-RUNX1 acute lymphoblastic leukemia (ALL) at high resolution. The survey uncovered a vast range of low-frequency genetic variants that were undetected in conventional bulk assays, inclu...

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Literature Corpus work: 3150a388-4602-5dad-95db-4aab78844b85
DOI: 10.1101/117614

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