Article
Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia.
Blood - 11 Feb 2021
Albertí-Servera Llucia, Demeyer Sofie, Govaerts Inge, Swings Toon, De Bie Jolien, Gielen Olga, Brociner Marco, Michaux Lucienne, Maertens Johan, Uyttebroeck Anne, De Keersmaecker Kim, Boeckx Nancy, Segers Heidi, Cools Jan
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia that is most frequent in children and is characterized by the presence of few chromosomal rearrangements and 10 to 20 somatic mutations in protein-coding regions at diagnosis. The majority of T-ALL cases harbor activating mutations in NOTCH1 together with mutations in genes implicated in kinase signaling, transcriptional regulation, or protein...
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