Article
Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.
Leukemia - 1 Jun 2018
De Bie Jolien, Demeyer Sofie, Alberti-Servera Llucia, Geerdens Ellen, Segers Heidi, Broux Michaël, De Keersmaecker Kim, Michaux Lucienne, Vandenberghe Peter, Voet Thierry, Boeckx Nancy, Uyttebroeck Anne, Cools Jan
Abstract excerpt
Next-generation sequencing has provided a detailed overview of the various genomic lesions implicated in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL). Typically, 10-20 protein-altering lesions are found in T-ALL cells at diagnosis. However, it is currently unclear in which order these mutations are acquired and in which progenitor cells this is initiated. To address these questions, we used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.