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Article

SNF2 chromatin remodeler-family proteins FRG1 and -2 are required for RNA-directed DNA methylation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Groth Martin, Stroud Hume, Feng Suhua, Greenberg Maxim V C, Vashisht Ajay A, Wohlschlegel James A, Jacobsen Steven E, Ausin Israel

Abstract excerpt

DNA methylation in Arabidopsis thaliana is maintained by at least four different enzymes: DNA methyltransferase1 (MET1), chromomethylase3 (CMT3), domains rearranged methyltransferase2 (DRM2), and chromomethylase2 (CMT2). However, DNA methylation is established exclusively by the enzyme DRM2, which acts in the RNA-directed DNA methylation (RdDM) pathway. Some RdDM components belong to gene families and have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25425661
DOI: 10.1073/pnas.1420515111
PMCID: PMC4267348

Genes

FRG1
FRG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SNF2 chromatin remodeler-family proteins FRG1 and -2 are required for RNA-directed DNA methylation.PMID 25425661Read ↗

INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis.Semantic proximity Read ↗

Identification of genes required for de novo DNA methylation in Arabidopsis.Semantic proximity Read ↗

SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.Semantic proximity Read ↗

NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation.Semantic proximity Read ↗

The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana.Semantic proximity Read ↗

An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.Semantic proximity Read ↗

Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation.Semantic proximity Read ↗

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A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation.Semantic proximity Read ↗

Involvement of the Arabidopsis SWI2/SNF2 chromatin remodeling gene family in DNA damage response and recombination.Semantic proximity Read ↗

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