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Article

An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.

Nature - 6 May 2010

Gao Zhihuan, Liu Hai-Liang, Daxinger Lucia, Pontes Olga, He Xinjian, Qian Weiqiang, Lin Huixin, Xie Mingtang, Lorkovic Zdravko J, Zhang Shoudong, Miki Daisuke, Zhan Xiangqiang, Pontier Dominique, Lagrange Thierry, Jin Hailing, Matzke Antonius J M, Matzke Marjori, Pikaard Craig S, Zhu Jian-Kang

Abstract excerpt

DNA methylation is an important epigenetic mark in many eukaryotes. In plants, 24-nucleotide small interfering RNAs (siRNAs) bound to the effector protein, Argonaute 4 (AGO4), can direct de novo DNA methylation by the methyltransferase DRM2 (refs 2, 4-6). Here we report a new regulator of RNA-dir...

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Source

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Identifiers

PMID: 20410883
DOI: 10.1038/nature09025
PMCID: PMC2865564

Genes

RDM1
AGO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20410883-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.PMID 20410883Read ↗

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