Article
The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana.
PLoS genetics - 28 Oct 2010
Henderson Ian R, Deleris Angelique, Wong William, Zhong Xuehua, Chin Hang Gyeong, Horwitz Gregory A, Kelly Krystyna A, Pradhan Sriharsa, Jacobsen Steven E
Abstract excerpt
Eukaryotic DNA cytosine methylation can be used to transcriptionally silence repetitive sequences, including transposons and retroviruses. This silencing is stable between cell generations as cytosine methylation is maintained epigenetically through DNA replication. The Arabidopsis thaliana Dnmt3 cytosine methyltransferase ortholog DOMAINS rearranged methyltransferase2 (DRM2) is required for establishment of...
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