Article
Identification of genes required for de novo DNA methylation in Arabidopsis.
Epigenetics - 1 Mar 2011
Greenberg Maxim V C, Ausin Israel, Chan Simon W L, Cokus Shawn J, Cuperus Josh T, Feng Suhua, Law Julie A, Chu Carolyn, Pellegrini Matteo, Carrington James C, Jacobsen Steven E
Abstract excerpt
De novo DNA methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of the mammalian de novo methyltransferase DNMT3. DRM2 is targeted to DNA by small interfering RNAs (siRNAs) in a process known as RNA-directed DNA Methylation (RdDM). While several components of the RdDM pathway are known, a functional understanding of the underlying mechanism is far from complete. We employed...
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