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Article

NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation.

Genes & development - 1 Feb 2009

He Xin-Jian, Hsu Yi-Feng, Pontes Olga, Zhu Jianhua, Lu Jian, Bressan Ray A, Pikaard Craig, Wang Co-Shine, Zhu Jian-Kang

Abstract excerpt

RNA-directed DNA methylation (RdDM) is an RNAi-based mechanism for establishing transcriptional gene silencing in plants. The plant-specific RNA polymerases IV and V are required for the generation of 24-nucleotide (nt) siRNAs and for guiding sequence-specific DNA methylation by the siRNAs, respectively. However, unlike the extensively studied multisubunit Pol II, our current knowledge about Pol IV and Pol V is...

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Source

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Identifiers

PMID: 19204117
DOI: 10.1101/gad.1765209
PMCID: PMC2648547

Genes

AGO4
DRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation.PMID 19204117Read ↗

An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.Semantic proximity Read ↗

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A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development.Semantic proximity Read ↗

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