Article
A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development.
Genes & development - 1 Dec 2009
He Xin-Jian, Hsu Yi-Feng, Zhu Shihua, Liu Hai-Liang, Pontes Olga, Zhu Jianhua, Cui Xinping, Wang Co-Shine, Zhu Jian-Kang
Abstract excerpt
RNA-directed DNA methylation (RdDM) is a conserved mechanism for epigenetic silencing of transposons and other repetitive elements. We report that the rdm4 (RNA-directed DNA Methylation4) mutation not only impairs RdDM, but also causes pleiotropic developmental defects in Arabidopsis. Both RNA polymerase II (Pol II)- and Pol V-dependent transcripts are affected in the rdm4 mutant. RDM4 encodes a novel protein...
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