Article
Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients.
Drug design, development and therapy - 1 Jan 2014
Baek Hyunjeong, Han Seunghoon, Yim Dong-Seok, Kim Sung Joo, Lee Soo-Youn, Jang Hye Ryoun, Lee Jung Eun, Kim Dae Joong, Kim Yoon-Goo, Oh Ha Young, Huh Wooseong
Abstract excerpt
This study aimed to evaluate the change in the pharmacokinetics (PK) of cyclosporine in the non-steady-state period in the first week after renal transplantation; the factors influencing this change, including genetic variability; and the time point concentration that correlated best with drug exposure. Data were obtained from 69 patients, and PK studies were conducted on postoperative days (PODs) 2, 3, and 7....
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