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Optimizing Dose Conversion From IR-Tac to LCP-Tac Formulations in Renal Transplant Recipients: A Population Pharmacokinetic Modeling Study

2025-07-30

Abstract excerpt

<h4>Background: </h4> /Objectives: The extended-release once-daily tacrolimus (LCP-Tac) formulation demonstrates enhanced bioavailability and a sustained pharmacokinetic profile compared to the immediate-release twice-daily tacrolimus (IR-Tac) formulation. Switching from IR-Tac to LCP-Tac is emerging as a viable immunosuppressive strategy in clinical settings. This study aimed to examine the influence of genetics...

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Literature Corpus work
18f01000-bf58-5da4-812e-0a2abe673609
DOI
10.20944/preprints202507.2483.v1
Open publication

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