Article
The potential of steroids and xenobiotic receptor polymorphisms in forecasting cyclosporine pharmacokinetic variability in young kidney transplant recipients.
Pediatric transplantation - 1 Sept 2012
Ferraresso Mariano, Turolo Stefano, Belinghieri Mirco, Tirelli Amedea Silvia, Grillo Paolo, Groppali Elena, Edefonti Alberto, Ghio Luciana
Abstract excerpt
The steroids and xenobiotics receptor (SXR) up-regulates the expression and the synthesis of key enzymes in CyA metabolism. In this study, we examined the possible interactions between CyA exposure and SXR polymorphisms during the first year after renal transplantation. The study involved 66 pediatric renal transplant recipients (25 women and 41 men, mean age 13.9 ± 7.4 yr). All patients were genotyped for two...
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