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Article

CYP3A5 polymorphism effect on cyclosporine pharmacokinetics in living donor renal transplant recipients: analysis by population pharmacokinetics.

The Annals of pharmacotherapy - 1 Sept 2012

Song Joohan, Kim Myeong Gyu, Choi Boyoon, Han Na Young, Yun Hwi-Yeol, Yoon Jeong-Hyun, Oh Jung Mi

Abstract excerpt

BACKGROUND: Cyclosporine is often used to prevent allograft rejection in renal transplant recipients. However, cyclosporine has a narrow therapeutic window and large variability in its pharmacokinetics. Individual characteristics and genetic polymorphisms can cause the variation. Hence, it is important to determine the cause(s) of the variation in cyclosporine pharmacokinetics. To our knowledge, this is the first...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22947591
DOI: 10.1345/aph.1R004

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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