Article
Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014
Tan Si Hui, Senarath-Yapa Kshemendra, Chung Michael T, Longaker Michael T, Wu Joy Y, Nusse Roeland
Abstract excerpt
Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of all 19 Wnt genes and Wnt target gene Axin2 in the neonatal mouse bone by in situ hybridization, and demonstrated--to our knowledge for the first...
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