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Tracking gene expression during zebrafish osteoblast differentiation

22 Jan 2009

Abstract excerpt

The transcription factors RUNX2 and OSX have been shown to act sequentially to direct mammalian osteoblast differentiation. RUNX2 is required during the early stages of commitment and acts in part to activate Osx transcription. OSX and RUNX2 then act to direct transcription of bone matrix proteins. Here, we investigate the expression of these genes and others during zebrafish osteoblastogenesis. Using whole-mount...

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PMID: 19161246
DOI: 10.1002/dvdy.21838

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