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Article

Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.

Bone - 1 Sept 2014

McGee-Lawrence Meghan E, Carpio Lomeli R, Bradley Elizabeth W, Dudakovic Amel, Lian Jane B, van Wijnen Andre J, Kakar Sanjeev, Hsu Wei, Westendorf Jennifer J

Abstract excerpt

Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we examined the effects of Axin2 deficiency on the cleidocranial dysplasia (CCD) phenotype of Runx2(+/-) mice, focusing on...

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Identifiers

PMID: 24973690
DOI: 10.1016/j.bone.2014.06.022
PMCID: PMC4125446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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