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Article

Wnt5a regulates growth, patterning, and odontoblast differentiation of developing mouse tooth.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2011

Lin Minkui, Li Lu, Liu Chao, Liu Hongbing, He Fenglei, Yan Fuhua, Zhang Yanding, Chen Yiping

Abstract excerpt

Wnt/β-catenin signaling is essential for tooth development beyond the bud stage, but little is known about the role of non-canonical Wnt signaling in odontogenesis. Here we compared the expression of Wnt5a, a representative of noncanonical Wnts, with that of Ror2, the Wnt5a receptor for non-canonical signaling, in the developing tooth, and analyzed tooth phenotype in Wnt5a mutants. Wnt5a-deficient mice exhibit...

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Identifiers

PMID: 21246660
DOI: 10.1002/dvdy.22550
PMCID: PMC3023990

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