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Article

WNT/β-CATENIN modulates the axial identity of ES derived human neural crest

1 Jan 2019

Abstract excerpt

WNT/β-CATENIN signaling is critical for neural crest (NC) formation, yet magnitude effects of the signal remain ill-defined. Using a robust model of human NC formation based on human pluripotent stem cells (hPSCs), we expose that the WNT signal modulates the axial identity of NCs in a dose dependent manner, with low WNT leading to anterior OTX+, HOX- NC, and high WNT leading to posterior OTX-, HOX+ NC....

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PMID: 31399472
DOI: 10.1242/dev.175604

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