Article
Wnt8a and Wnt3a cooperate in the axial stem cell niche to promote mammalian body axis extension.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2015
Cunningham Thomas J, Kumar Sandeep, Yamaguchi Terry P, Duester Gregg
Abstract excerpt
BACKGROUND: Vertebrate body axis extension occurs in a head-to-tail direction from a caudal progenitor zone that responds to interacting signals. Wnt/β-catenin signaling is critical for generation of paraxial mesoderm, somite formation, and maintenance of the axial stem cell pool. Body axis extension requires Wnt8a in lower vertebrates, but in mammals Wnt3a is required, although the anterior trunk develops in the...
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