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Mycobacterium tuberculosis rrs A1401G mutation correlates with high-level resistance to kanamycin, amikacin, and capreomycin in clinical isolates from mainland China.

Diagnostic microbiology and infectious disease - 1 Oct 2013

Du Qinglin, Dai Guangming, Long Quanxin, Yu Xia, Dong Lingling, Huang Hairong, Xie Jianping

Abstract excerpt

Mutations correlating phenotypic resistance level with the injectable second-line anti-tuberculosis drugs (SLDs) including kanamycin (KAN), amikacin (AMK), and capreomycin (CAP) remain elusive. A collection of 114 Mycobacterium tuberculosis clinical isolates from mainland China was analyzed. The minimum inhibitory concentration (MIC) of each strain was determined and the sequences of rrs, tlyA, promoter of eis as...

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Identifiers

PMID: 23948547
DOI: 10.1016/j.diagmicrobio.2013.06.031

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