Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

doi:10.1038/nm.3750

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Article

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

Nature medicine - 1 Jan 2015

Davis Hayley, Irshad Shazia, Bansal Mukesh, Rafferty Hannah, Boitsova Tatjana, Bardella Chiara, Jaeger Emma, Lewis Annabelle, Freeman-Mills Luke, Giner Francesc Castro, Rodenas-Cuadrado Pedro, Mallappa Sreelakshmi, Clark Susan, Thomas Huw, Jeffery Rosemary, Poulsom Richard, Rodriguez-Justo Manuel, Novelli Marco, Chetty Runjan, Silver Andrew, Sansom Owen James, Greten Florian R, Wang Lai Mun, East James Edward, Tomlinson Ian, Leedham Simon John

Abstract excerpt

Hereditary mixed polyposis syndrome (HMPS) is characterized by the development of mixed-morphology colorectal tumors and is caused by a 40-kb genetic duplication that results in aberrant epithelial expression of the gene encoding mesenchymal bone morphogenetic protein antagonist, GREM1. Here we use HMPS tissue and a mouse model of the disease to show that epithelial GREM1 disrupts homeostatic intestinal morphogen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

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Identifiers

PMID: 25419707
DOI: 10.1038/nm.3750
PMCID: PMC4594755

Genes

GREM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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