Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of LGR5 stem cells in colorectal adenomas and carcinomas

2 Mar 2015

Abstract excerpt

LGR5 is known to be a stem cell marker in the murine small intestine and colon, however the localization of LGR5 in human adenoma samples has not been examined in detail, and previous studies have been limited by the lack of specific antibodies. Here we used in situ hybridization to specifically examine LGR5 mRNA expression in a panel of human adenoma and carcinoma samples (n = 66). We found that a small number...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Genetic factors in colorectal cancer
Share to Metastasis and carcinoma case studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25728748
DOI: 10.1038/srep08654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of LGR5 stem cells in colorectal adenomas and carcinomasPMID 25728748Read ↗

Distribution of intestinal stem cell markers in colorectal precancerous lesionsSemantic proximity Read ↗

Identification, isolation and characterization of human LGR5-positive colon adenoma cellsSemantic proximity Read ↗

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma CellsSemantic proximity Read ↗

The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical StudySemantic proximity Read ↗

Distribution of LGR5+ Cells and Associated Implications during the Early Stage of Gastric TumorigenesisSemantic proximity Read ↗

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number of LGR5+ Ectopic Stem CellsSemantic proximity Read ↗

Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applicationsSemantic proximity Read ↗

Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinomaSemantic proximity Read ↗

LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell LinesSemantic proximity Read ↗

In situ validation of an intestinal stem cell signature in colorectal cancer.Semantic proximity Read ↗

Stem cells and their implications for colorectal cancer.Semantic proximity Read ↗

Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.