Article
Oxyphil cell metaplasia in the parathyroids is characterized by somatic mitochondrial DNA mutations in NADH dehydrogenase genes and cytochrome c oxidase activity-impairing genes.
The American journal of pathology - 1 Nov 2014
Müller-Höcker Josef, Schäfer Sabine, Krebs Stefan, Blum Helmut, Zsurka Gábor, Kunz Wolfram S, Prokisch Holger, Seibel Peter, Jung Andreas
Abstract excerpt
Oxyphil cell transformation of epithelial cells due to the accumulation of mitochondria occurs often during cellular aging. To understand the pathogenic mechanisms, we studied mitochondrial DNA (mtDNA) alterations in the three cell types of the parathyroids using multiplex real-time PCR and next-...
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