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Near-haploidization significantly associates with oncocytic adrenocortical, thyroid, and parathyroid tumors but not with mitochondrial DNA mutations.

Genes, chromosomes & cancer - 1 Oct 2014

Corver Willem E, van Wezel Tom, Molenaar Kees, Schrumpf Melanie, van den Akker Brendy, van Eijk Ronald, Ruano Neto Dina, Oosting Jan, Morreau Hans

Abstract excerpt

Mitochondrial-rich oncocytic thyroid tumors frequently show near-haploidization and endoreduplication (masked haploidization), which manifests as a near-homozygous genome (NHG). We now extend this investigation to include adrenocortical cancer and parathyroid carcinoma (PaTC), which we studied for a NHG in association with mitochondrial DNA mutations. Sixty endocrine tumors from 59 patients were studied,...

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PMID: 24909752
DOI: 10.1002/gcc.22194

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