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Article

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes.

Nature reviews. Rheumatology - 1 Jun 2018

Blanco Francisco J, Valdes Ana M, Rego-Pérez Ignacio

Abstract excerpt

Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses of the cell, and also regulate different processes involved in the pathogenesis of OA including inflammation, apoptosis, calcium metabolism and the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS)....

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PMID: 29670212
DOI: 10.1038/s41584-018-0001-0

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