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Article

Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas

4 Oct 2007

Abstract excerpt

BACKGROUND: The potential pathogenetic significance of mitochondrial DNA (mtDNA) mutations in tumorigenesis is controversial. We hypothesized that benign tumorigenesis of a slowly replicating tissue like the human parathyroid might constitute an especially fertile ground on which a selective advantage conferred by mtDNA mutation could be manifested and might contribute to the oxyphilic phenotype observed in a...

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Share to Dermatological and Skeletal Disorders
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PMID: 17916247
DOI: 10.1186/1472-6823-7-8

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