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Oncocytic tumors are marked by enhanced mitochondrial content and mtDNA mutations of complex I in Chinese patients.

Mitochondrion - 1 Mar 2019

Lyu Lihua, Wang Qiufeng, Song Shujie, Li Liyan, Zhou Huaibin, Li Ming, Jiang ZhiYing, Zhou Chen, Chen Guorong, Lyu Jianxin, Bai Yidong

Abstract excerpt

Oncocytic tumors are composed of oncocytes characterized by acidophilic granular and reticular cytoplasm. Such features have been attributed to the distinctive aggregation of abnormal mitochondria. Sporadic mitochondrial DNA (mtDNA) mutations, particularly those in complex I subunit genes, have been identified as one of the most noticeable alterations. We reviewed 11,051 cases of patients with thyroid tumors who...

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Identifiers

PMID: 29386142
DOI: 10.1016/j.mito.2018.01.008

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