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Article

Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner.

Behavior genetics - 1 May 2015

Ford Matthew M, Nickel Jeffrey D, Kaufman Moriah N, Finn Deborah A

Abstract excerpt

The neuroactive steroid allopregnanolone (ALLO) is a positive modulator of GABAA receptors, and manipulation of neuroactive steroid levels via injection of ALLO or the 5α-reductase inhibitor finasteride alters ethanol self-administration patterns in male, but not female, mice. The Srd5a1 gene encodes the enzyme 5α-reductase-1, which is required for the synthesis of ALLO. The current studies investigated the...

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Identifiers

PMID: 25416204
DOI: 10.1007/s10519-014-9694-2
PMCID: PMC4425631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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