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Article

The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice.

Brain research - 3 Dec 2008

Gililland-Kaufman Katherine R, Tanchuck Michelle A, Ford Matthew M, Crabbe John C, Beadles-Bohling Amy S, Snelling Christopher, Mark Gregory P, Finn Deborah A

Abstract excerpt

The progesterone derivative allopregnanolone (ALLO) rapidly potentiates gamma-aminobutyric acid(A) (GABA(A)) receptor mediated inhibition. The present studies determined whether specific manipulation of neurosteroid levels in the hippocampus would alter seizure susceptibility in an animal model genetically susceptible to severe ethanol (EtOH) withdrawal, Withdrawal Seizure-Prone (WSP) mice. Male WSP mice were...

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Identifiers

PMID: 18840414
DOI: 10.1016/j.brainres.2008.09.042
PMCID: PMC2613069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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