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Article

Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains.

Alcohol (Fayetteville, N.Y.) - 1 Feb 2017

Porcu Patrizia, O'Buckley Todd K, Lopez Marcelo F, Becker Howard C, Miles Michael F, Williams Robert W, Morrow A Leslie

Abstract excerpt

Neuroactive steroids modulate alcohol's impact on brain function and behavior. Ethanol exposure alters neuroactive steroid levels in rats, humans, and some mouse strains. We conducted an exploratory analysis of the neuroactive steroids (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP), (3α,5α)-3,21-dihydroxypregnan-20-one (3α,5α-THDOC), and pregnenolone across 126-158 individuals and 19 fully inbred strains belonging...

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Identifiers

PMID: 27884493
DOI: 10.1016/j.alcohol.2016.07.011
PMCID: PMC5253318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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