Article
Gonadal hormones and sex chromosome complement differentially contribute to ethanol intake, preference, and relapse-like behaviour in four core genotypes mice.
Addiction biology - 1 Sept 2022
Sneddon Elizabeth A, Rasizer Lindsay N, Cavalco Natalie G, Jaymes Asa H, Ostlie Noah J, Minshall Brianna L, Masters Brianna M, Hughes Michael R, Hrncir Haley, Arnold Arthur P, Radke Anna K
Abstract excerpt
Alcohol use and high-risk alcohol drinking behaviours among women are rapidly rising. In rodent models, females typically consume more ethanol (EtOH) than males. Here, we used the four core genotypes (FCG) mouse model to investigate the influence of gonadal hormones and sex chromosome complement on EtOH drinking behaviours. FCG mice were given access to escalating concentrations of EtOH in a two-bottle, 24-h...
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