Article

Estrogen receptor alpha regulates alcohol craving in females: convergent evidence from mouse models and human genetics

2026-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Alcohol craving and consumption fluctuate across the reproductive cycle in females with alcohol use disorder (AUD), suggesting that estrogen signaling contributes to disease vulnerability. Here, we investigated the role of estrogen receptor alpha (ERα; Esr1 ; ESR1 ) in alcohol seeking using complementary mouse and human approaches, as this receptor was previously identified as a risk factor fo...

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Literature Corpus work: 5884a6da-df8f-5887-9b5a-38609831989c
DOI: 10.64898/2026.06.03.729849

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