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Article

Sex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene.

Behavior genetics - 1 May 2015

Tanchuck-Nipper Michelle A, Ford Matthew M, Hertzberg Anna, Beadles-Bohling Amy, Cozzoli Debra K, Finn Deborah A

Abstract excerpt

Manipulation of endogenous levels of the GABAergic neurosteroid allopregnanolone alters sensitivity to some effects of ethanol. Chronic ethanol withdrawal decreases activity and expression of 5α-reductase-1, an important enzyme in allopregnanolone biosynthesis encoded by the 5α-reductase-1 gene (Srd5a1). The present studies examined the impact of Srd5a1 deletion in male and female mice on several acute effects of...

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Identifiers

PMID: 25355320
DOI: 10.1007/s10519-014-9691-5
PMCID: PMC4417087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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