Article
Centromere sliding on a mammalian chromosome.
Chromosoma - 1 Jun 2015
Purgato Stefania, Belloni Elisa, Piras Francesca M, Zoli Monica, Badiale Claudia, Cerutti Federico, Mazzagatti Alice, Perini Giovanni, Della Valle Giuliano, Nergadze Solomon G, Sullivan Kevin F, Raimondi Elena, Rocchi Mariano, Giulotto Elena
Abstract excerpt
The centromere directs the segregation of chromosomes during mitosis and meiosis. It is a distinct genetic locus whose identity is established through epigenetic mechanisms that depend on the deposition of centromere-specific centromere protein A (CENP-A) nucleosomes. This important chromatin domain has so far escaped comprehensive molecular analysis due to its typical association with highly repetitive satellite...
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