Article

Contextualising transcription factor binding during embryogenesis using natural sequence variation

2024-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Understanding how genetic variation impacts transcription factor (TF) binding remains a major challenge, limiting our ability to model disease-associated variants. Here, we used a highly controlled system of F1 crosses with extensive genetic diversity to profile allele-specific binding of four TFs at several embryonic time-points, using Drosophila as a model. Using a combined haplotype test, we...

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Literature Corpus work: 726e3450-0c3b-50d8-ae74-01de3bd27329
DOI: 10.1101/2024.10.24.619975

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