Article
Angiotensin II increases fibronectin and collagen I through the β-catenin-dependent signaling in mouse collecting duct cells.
American journal of physiology. Renal physiology - 15 Feb 2015
Cuevas Catherina A, Gonzalez Alexis A, Inestrosa Nibaldo C, Vio Carlos P, Prieto Minolfa C
Abstract excerpt
The contribution of angiotensin II (ANG II) to renal and tubular fibrosis has been widely reported. Recent studies have shown that collecting duct cells can undergo mesenchymal transition suggesting that collecting duct cells are involved in interstitial fibrosis. The Wnt/β-catenin signaling pathway plays an essential role in development, organogenesis, and tissue homeostasis; however, the dysregulation of this...
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