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Article

Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.

American journal of physiology. Renal physiology - 1 Oct 2017

Mamuya Fahmy A, Xie Dongping, Lei Lei, Huang Ming, Tsuji Kenji, Capen Diane E, Yang BaoXue, Weissleder Ralph, Păunescu Teodor G, Lu Hua A Jenny

Abstract excerpt

The renal collecting duct (CD) contains two major cell types, intercalated (ICs) and principal cells (PCs). A previous report showed that deletion of β1-integrin in the entire renal CD causes defective CD morphogenesis resulting in kidney dysfunction. However, subsequent deletion of β1-integrin specifically in ICs and PCs, respectively, did not cause any morphological defects in the CDs. The discrepancy between...

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Identifiers

PMID: 28701310
DOI: 10.1152/ajprenal.00038.2017
PMCID: PMC5668581

Genes

AQP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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